Who We Are Products & Services Business Operations CSR & Sustainability
Company Profile What We Believe Where We Are What’s New
API Intermediates CDMO
R&D System Manufacturing Facilties Quality System
CSR Governance Green EHS
CN 丨 EN
CN
Who We Are
Company Profile What We Believe Where We Are What’s New
Products & Services
API Intermediates CDMO
Business Operations
R&D System Manufacturing Facilties Quality System
CSR & Sustainability
CSR Governance Green EHS
Tianyu Pharm's CDMO business provides one-stop services from clinical phase I to commercial production
for a wide range of domestic and international pharmaceutical customers.
 
Contact us：CDMO@tianyupharm.com

ONE-STOP CDMO SERVICES：

Phase I

Phase II

Phase III

Registration & Commercialization

RSMs intermediates APIs
Process R&D, Solid State Chemistry
RSMs, Intermediates & APIs Manufacturing
Analytics
Analytical Development, QC, Stability Studies
Regulatory Affairs
Global Regulatory CMC & DMF Filing Support
Drug Products
Pre-formulation Study and Formulation DevelopmentDrug Products Manufacturing

KILO LABS FOR PRODUCTION OF VARIOUS SPECIFICATIONS AT PILOT-SCALE

Location
Kilo Lab Reactor Qty.
Reaction Vo1. (L)
Temp. Range (°c)
Max. Pressure (MPa)
Max. Amount (kg)

Changzhou
R&D Center

2
0.01~20
-78~120
2.0
2

Huangyan
R&D Center

8
10/20
-50~200
0.3
20

Shanghai
R&D Center

6
10/30/50
-45-200
0.1
5

0

cGMP Sites

0

Kilo Labs

Tianyu pharm's core technologies include:

Tianyu Pharm has 6 lab-scale reactors for flow chemistry process development. So far Tianyu has developed flow chemical processes for several products and realized commercial productions for diazotization, photo-oxidation, lithiation and nitration reactions by applying flow chemical processes.

Reaction Type：Photo-Oxidation Reaction

Reaction Type：Photo-Oxidation Reaction

Designed Capacity：1500 mt/yr

Reaction Type：Diazotization

Reaction Type：Diazotization

Designed Capacity：900 mt/yr

Reaction Type：Nitration

Reaction Type：Nitration

Designed Capacity：800 mt/yr

Reaction Type：Lithiation

Reaction Type：Lithiation

Designed Capacity：500 mt/yr

The types of enzymes we currently have and the corresponding reactions that can be developed：

Transaminases                 Asymmetric conversion of ketones to chiral amines

Ketoreductases                Reductions of ketones to chiral alcohols

Nitrilases                          Asymmetric hydrolysis of nitriles to carboxylic acids

Imine reductases              Asymmetric conversion of ketones/imines/ to chiral amines

Monoamine Oxidases       Oxidation from amines to imines with O2 atmosphere

Esterases                          Efficient hydrolysis from esters to carboxylic acids

Acylases                           Resolution and formation of esters

Nitrile reductases              Reductions of nitriles to amines


Tianyu can provide enzyme screening services：

Tianyu currently has TECAN SPARCK20 microplate reader, which can provide high-throughput enzyme linked reaction screening.


Tianyu has a number of LC-MS and GC-MS equipment that can be used for online screening of enzyme-catalyzed reactions.


Tianyu provides Artificial Enzyme Screening Service (FTE).


The types of enzymes that are being expanded and the corresponding reactions :

Acylases                    Resolution and formation of esters


 Nitrile reductases       Reductions of nitriles to amines


SPRAY DRYING TECHNOLOGY

CAPABILITIES
1. 4 spray dryers covering from lab to commercial scale
2. Manufacturing capability for both general and antitumor drugs
CAPACITY
2 commercial spray dryers with the capacity of 20kg/hand 50kg/h (DCM evaporation) respectively

Who We Are

Company Profile What We Believe Where We Are What’s New

Products & Services

API Intermediates CDMO

Business Operations

R&D System Manufacturing Facilties Quality System

CSR & Sustainability

CSR Governance Green EHS

Stock code

300702

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